The overall goal of the epiCURE Skin Immunity, Integrity and Disease Core (SIND) is to facilitate high-quality skin-focused translational research. Ongoing research increasingly recognizes the intricate coordination of skin function by a multitude of neuro-immuno-endocrine regulatory systems, which are subject to both internal and external stresses (e.g., solar radiation and microbial pathogens).
The epiCURE Skin Stem Cell Imaging and Manipulation Core (SCIM) was established to facilitate skin disease research via the propagation and manipulation of various state of the art in vitro and in vivo experimental systems that model skin biology. To assist epiCURE investigators in the phenotypic and mechanistic analyses of skin disease, the SCIM will provide a wide array of histological, immunohistochemical, and molecular-based tools to characterize gross and microscopic morphology, functional features and gene expression in skin of human and genetically engineered laboratory animals.
In collaboration with Dr. David Brenner in the Center for Radiological Research, our Department of Dermatology NIH-designated epiCURE Core facilities conducted studies to assess the safety and efficacy of short wave UVC light on human skin cells.
PubMed Citations: Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light