Research
T lymphocytes cells have been implicated in mediating some aspects of skin autoimmune inflammation such as alopecia areata, vitiligo and psoriasis. Therefore, approaches that effectively halt the pathogenic T cell response are predicted to have therapeutic benefit for T-cell mediated autoimmune disease treatment. T cells rely on a duality of TCR and gamma chain cytokine signals for development, activation and peripheral T cell homeostasis. Our research focuses on using antibodies or small molecular compounds to deplete the pathogenic T cells, suppress their function, or inhibit their migration into the skin for treatment of T-cell mediated autoimmune disease such as alopecia areata and other skin autoimmune inflammation.
Research Interests
Role of gamma chain cytokines in the pathogenies of skin autoimmune inflammation
Grants
FUNCTIONAL STUDIES OF THE IL-7/IL-7R SIGNALING PATHWAY IN ALOPECIA AREATA (Federal Gov)
July 15 2017-June 30 2022
COLUMBIA UNIVERSITY SKIN DISEASE RESOURCE-BASED CENTER (EPICURE) (Federal Gov)
Aug 1 2016 - Jul 31 2021
MECHANISTIC STUDIES OF INTERLEUKIN-7 SIGNALING PATHWAY IN ALOPECIA AREATA (Private)
Jan. 01 2016- Apr. 30 2020