T lymphocytes cells have been implicated in mediating some aspects of skin autoimmune inflammation such as alopecia areata, vitiligo and psoriasis. Therefore, approaches that effectively halt the pathogenic T cell response are predicted to have therapeutic benefit for T-cell mediated autoimmune disease treatment. T cells rely on a duality of TCR and gamma chain cytokine signals for development, activation and peripheral T cell homeostasis. Our research focuses on using antibodies or small molecular compounds to deplete the pathogenic T cells, suppress their function, or inhibit their migration into the skin for treatment of T-cell mediated autoimmune disease such as alopecia areata and other skin autoimmune inflammation.
Role of gamma chain cytokines in the pathogenies of skin autoimmune inflammation
FUNCTIONAL STUDIES OF THE IL-7/IL-7R SIGNALING PATHWAY IN ALOPECIA AREATA (Federal Gov)
July 15 2017-June 30 2022
COLUMBIA UNIVERSITY SKIN DISEASE RESOURCE-BASED CENTER (EPICURE) (Federal Gov)
Aug 1 2016 - Jul 31 2021
MECHANISTIC STUDIES OF INTERLEUKIN-7 SIGNALING PATHWAY IN ALOPECIA AREATA (Private)
Jan. 01 2016- Apr. 30 2020