The overall goal of the epiCURE Skin Immunity, Integrity and Disease Core (SIND) is to facilitate high-quality skin-focused translational research. Ongoing research increasingly recognizes the intricate coordination of skin function by a multitude of neuro-immuno-endocrine regulatory systems, which are subject to both internal and external stresses (e.g., solar radiation and microbial pathogens). Therefore, in vivo and ex vivo models that aim to mimic disease relevant aspects of human skin are essential for understanding normal and pathological skin physiology as well as identification and preclinical proof of concept studies of novel therapies for skin diseases.